Human HAP1(Huntingtin Associated Protein 1) ELISA Kit

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Huntingtin Associated Protein 1 (HAP1) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Huntingtin Associated Protein 1 (HAP1) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Huntingtin Associated Protein 1 (HAP1) in Tissue homogenates and other biological fluids.

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Huntingtin Associated Protein 1 (HAP1) in Tissue homogenates and other biological fluids.

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Huntingtin Associated Protein 1 (HAP1) in samples from Tissue homogenates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Description: Recombinant Human Huntingtin Associated Protein 1 expressed in: E.coli

Description: Recombinant Mouse Huntingtin Associated Protein 1 expressed in: E.coli

Description: Recombinant Rat Huntingtin Associated Protein 1 expressed in: E.coli

Description: Huntingtin-associated protein 1 (HAP1) is a protein which in humans is encoded by the HAP1 gene. Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Description: A sandwich ELISA kit for detection of Huntingtin Associated Protein 1 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1)

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1)

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1)

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Biotin.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with Cy3.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with FITC.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with HRP.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with PE.

Description: A Rabbit polyclonal antibody against Human Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Mouse Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Description: A Rabbit polyclonal antibody against Rat Huntingtin Associated Protein 1 (HAP1). This antibody is labeled with APC-Cy7.

Description: Rabbit polyclonal to Huntingtin Associated Protein 1

Description: Quantitativesandwich ELISA kit for measuring Human Huntingtin(HTT) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Description: Description of target: Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to faciltate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca2+ release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).1 Publication <p>Manually curated information for which there is published experimental evidence.</p> <p><a href="/manual/evidences#ECO:0000269">More…</a></p> Manual assertion based on experiment iniRef.9"Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued."_x005F_x005F_x000D_Shimojo M._x005F_x005F_x000D_J. Biol. Chem. 283:34880-34886(2008) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION. ;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: < 0.113 ng/mL